Self-Organizing Global Gene Expression Regulated through Criticality: Mechanism of the Cell-Fate Change.

ABSTRACT:

Background

A fundamental issue in bioscience is to understand the mechanism that underlies the dynamic control of genome-wide expression through the complex temporal-spatial self-organization of the genome to regulate the change in cell fate. We address this issue by elucidating a physically motivated mechanism of self-organization.

Principal findings

Building upon transcriptome experimental data for seven distinct cell fates, including early embryonic development, we demonstrate that self-organized criticality (SOC) plays an essential role in the dynamic control of global gene expression regulation at both the population and single-cell levels. The novel findings are as follows: i) Mechanism of cell-fate changes: A sandpile-type critical transition self-organizes overall ex

SUBMITTER: Tsuchiya M 

PROVIDER: S-EPMC5173342 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature