Spatiotemporal Dynamics of Virus Infection Spreading in Tissues.

ABSTRACT: Virus spreading in tissues is determined by virus transport, virus multiplication in host cells and the virus-induced immune response. Cytotoxic T cells remove infected cells with a rate determined by the infection level. The intensity of the immune response has a bell-shaped dependence on the concentration of virus, i.e., it increases at low and decays at high infection levels. A combination of these effects and a time delay in the immune response determine the development of virus infection in tissues like spleen or lymph nodes. The mathematical model described in this work consists of reaction-diffusion equations with a delay. It shows that the different regimes of infection spreading like the establishment of a low level infection, a high level infection or a transition between both ar

SUBMITTER: Bocharov G 

PROVIDER: S-EPMC5173377 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature