PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen.

ABSTRACT: In allergic asthma, inhalation of airborne allergens such as the house dust mite (HDM) effectively activates both innate and adaptive immunity in the lung mucosa. To determine the role of the eicosanoid PGI₂ and its receptor IP during allergic airway sensitization, HDM responses in mice lacking a functional IP receptor (i.e., PGI₂ IP receptor-deficient [IP^-/-]) were compared with wild type (WT) mice. Surprisingly, IP^-/- mice had increased numbers of pulmonary CD3^-NK1.1⁺Ly49b⁺ NK cells producing IFN-γ that was inversely associated with the number of type 2 innate lymphoid cells (ILC2s) expressing IL-33Rα and IL-13 compared with WT animals. This phenomenon was associated with elevated CX₃CL1 levels in the

SUBMITTER: Simons B 

PROVIDER: S-EPMC5173397 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature