Timing of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment.

ABSTRACT:

Objectives

To investigate the timing (mid- vs late life) of physical activity, apolipoprotein (APO)E ε4, and risk of incident mild cognitive impairment (MCI).

Design

Prospective cohort study.

Setting

Mayo Clinic Study of Aging (Olmsted County, MN).

Participants

Cognitively normal elderly adults (N = 1,830, median age 78, 50.2% female).

Measurements

Light, moderate, and vigorous physical activities in mid- and late life were assessed using a validated questionnaire. An expert consensus panel measured MCI based on published criteria. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) with age as a time scale after adjusting for sex, education, medical comorbidity, and depression.

Results

Lig

SUBMITTER: Krell-Roesch J 

PROVIDER: S-EPMC5173416 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature