Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study.

ABSTRACT:

Background

Moderate alcohol consumption is thought to confer cardiometabolic protective effects. Inflammatory pathways are hypothesized to partly underlie this association.

Objectives

The aim of this study was to examine the association between typologies of alcohol consumption and markers of inflammation, and their rate of change over time.

Methods

Data were collected from 8209 participants [69% men; mean age, 50 years (SD 6.1)] of the British Whitehall II study. Alcohol consumption typologies were defined using up to three measures during an approximately 10-year period spanning from 1985 to 1994 as (i) stable nondrinkers, (ii) stable moderate drinkers (referent), (iii) stable heavy drinkers, (iv) nonstable drinkers and (v) former drinkers. C-reactive protein (CRP),

SUBMITTER: Bell S 

PROVIDER: S-EPMC5173424 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature