The Mark Coventry, MD, Award: Oral Antibiotics Reduce Reinfection After Two-Stage Exchange: A Multicenter, Randomized Controlled Trial.

ABSTRACT:

Background

Many patients develop recurrent periprosthetic joint infection after two-stage exchange arthroplasty of the hip or knee. One potential but insufficiently tested strategy to decrease the risk of persistent or recurrent infection is to administer additional antibiotics after the second-stage reimplantation.

Questions/purposes

(1) Does a 3-month course of oral antibiotics decrease the risk of failure secondary to infection after a two-stage exchange? (2) Are there any complications related to the administration of oral antibiotics after a two-stage exchange? (3) In those patients who develop a reinfection, is the infecting organism different from the initial infection?

Methods

Patients at seven centers randomized to receive 3 months of oral antibiotics or no f

SUBMITTER: Frank JM 

PROVIDER: S-EPMC5174034 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature