FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise.

ABSTRACT: Mice are commonly used to examine the mechanisms by which exercise improves cardiometabolic health; however, exercise compliance and adaptations are often strain-dependent or are variable due to inconsistency in exercise training protocols. In this study, we examined nocturnal/diurnal behavior, treadmill exercise compliance, and systemic as well as cardiac-specific exercise adaptations in two commonly used mouse strains, C57BL/6J, and FVB/NJ mice. Metabolic cage analysis indicated a strong nocturnal nature of C57BL/6J mice, whereas FVB/NJ mice showed no circadian element to activity, food or water intake, VO₂, or VCO₂. Initial exercise capacity tests revealed that, compared with C57BL/6J mice, FVB/NJ mice are capable of achieving nearly 2-fold higher workloads prior t

SUBMITTER: Gibb AA 

PROVIDER: S-EPMC5174104 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature