CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.

ABSTRACT: Lymphopenic conditions lead to expansion of memory-like T cells (T_ML), which develop from naïve T cells by spontaneous proliferation. T_ML cells are often increased in the elderly population, AIDS patients, and patients recovering from radio- or chemotherapy. At present, it is unclear whether T_ML cells can efficiently respond to foreign antigen and participate in antiviral immunity. To address this question, we analyzed the immune response during acute low-dose infection with lymphocytic choriomeningitis virus-WE in T cell lymphopenic CD4Cre/R-diphtheria toxin alpha (DTA) mice in which most peripheral T cells show a T_ML phenotype. On day 8 after infection, the total number of effector T cells and polyfunctional IFN-γ and TNF-α producing CD8 T cell

SUBMITTER: Schmitt ME 

PROVIDER: S-EPMC5174106 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature