Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach.

ABSTRACT:

Objective

To develop and validate a responsive and feasible ultrasound inflammation score for rheumatoid arthritis (RA).

Methods

We used data from cohorts of early RA (development) and established RA starting/switching biologic therapy (validation). 4 tendons and 36 joints were examined by a grey scale (GSUS) and power Doppler semiquantitative ultrasound (PDUS) scoring system (full score). Ultrasound score components were selected based on factor analyses of 3-month change in the development cohort. Responsiveness was assessed by standardised response means (SRMs). We assessed the proportion of information retained from the full score by linear regression.

Results

118 patients with early and 212 patients with established RA were included. The final ultrasound score in

SUBMITTER: Aga AB 

PROVIDER: S-EPMC5174791 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature