Automatic annotation of protein motif function with Gene Ontology terms.

ABSTRACT:

Background

Conserved protein sequence motifs are short stretches of amino acid sequence patterns that potentially encode the function of proteins. Several sequence pattern searching algorithms and programs exist foridentifying candidate protein motifs at the whole genome level. However, a much needed and important task is to determine the functions of the newly identified protein motifs. The Gene Ontology (GO) project is an endeavor to annotate the function of genes or protein sequences with terms from a dynamic, controlled vocabulary and these annotations serve well as a knowledge base.

Results

This paper presents methods to mine the GO knowledge base and use the association between the GO terms assigned to a sequence and the motifs matched by the same sequence as evidence

SUBMITTER: Lu X 

PROVIDER: S-EPMC517493 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature