Parental life events cause behavioral difference among offspring: Adult pre-gestational restraint stress reduces anxiety across generations.

ABSTRACT: While effects of gestational, neonatal or adolescent stress on psychological alterations in progeny have been extensively studied, much less is known regarding the effects of adult pre-gestational life events on offspring behavior. Although full siblings often display behavioral differences, whether the different parental life events prior to different pregnancies contribute to these behavioral differences among siblings is worth studying. In this study, male and female adult mice were restrained for 60 days before mating with unstressed or stressed partners. F1 offspring were examined for anxiety or mated to generate F2. Both F1 females and males from restrained mothers and/or fathers showed significantly reduced anxiety and serum cortisol and increased mRNA levels of glucocorticoid recep

SUBMITTER: He N 

PROVIDER: S-EPMC5175168 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature