Sustained Elevation of Intraocular Pressure Associated with Intravitreal Administration of Anti-vascular Endothelial Growth Factor: A Systematic Review and Meta-Analysis.

ABSTRACT: This study aimed to assess whether repetitive intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) cause sustained elevation of intraocular pressure (SE-IOP). We conducted a systematic review and meta-analysis based on five randomized controlled trials (RCTs) assessing 1428 subjects and 17 non-RCTs evaluating 8358 cases. In the RCTs, an increased risk of SE-IOP was found in the anti-VEGF group (summary risk ratio [RR] = 3.00, 95% confidence interval [CI]: 1.63-5.53) compared with the sham injection or laser group. The increased risk of SE-IOP was correlated with follow-up duration (RR = 2.14, 95% CI 0.69-6.57 at 6 months; RR = 3.15, 95% CI 0.99-10.09 at 12 months; RR = 3.48, 95% CI 1.38-8.78 at 23 months). The risk of SE-IOP after non-exclusion of pre-existi

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5175276 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature