Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging.

ABSTRACT: The penetration of anticancer drugs in solid tumors is important to ensure the therapeutic effect, so methods are needed to understand drug distribution in different parts of the tumor. Mass spectrometry imaging (MSI) has great potential in this field to visualize drug distribution in organs and tumor tissues with good spatial resolution and superior specificity. We present an accurate and reproducible imaging method to investigate the variation of drug distribution in different parts of solid tumors. The method was applied to study the distribution of paclitaxel in three ovarian cancer models with different histopathological characteristics and in colon cancer (HCT116), breast cancer (MDA-MB-231) and malignant pleural mesothelioma (MPM487). The heterogeneous drug penetration in the tumors

SUBMITTER: Giordano S 

PROVIDER: S-EPMC5175283 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature