Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults.

ABSTRACT:

Objectives:

The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events.

Methods:

Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA).

Results:

Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous oc

SUBMITTER: Paula RS 

PROVIDER: S-EPMC5175288 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature