Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model.

ABSTRACT:

Objective

Inflammation plays a key role in the pathophysiological processes after intracerebral hemorrhage (ICH). Post-ICH macrophages infiltrate the brain and release pro-inflammatory factors (tumor necrosis factor-α), amplifying microglial activation and neutrophil infiltration. Platelet-derived growth factor receptor-β (PDGFR-β) is expressed on macrophages and it's activation induces the recruitment of macrophages. Platelet-derived growth factor-D (PDGF-D) is an agonist with a significantly higher affinity to the PDGFR-β compared to another isoform of the receptor. In this study, we investigated the role of PDGF-D in the pro-inflammatory response after ICH in mice.

Methods

A blood injection model of ICH was used in eight-week old male CD1 mice (weight 30g). Some mice rece

SUBMITTER: Yang P 

PROVIDER: S-EPMC5175487 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature