Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study.

ABSTRACT:

Objective

Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study of serum C-reactive protein (CRP) in adolescence and subsequent risk of schizophrenia and related psychoses in adulthood in the Northern Finland Birth Cohort 1986.

Method

Serum high-sensitivity CRP was measured at age 15/16 years in 6362 participants. ICD-10 diagnoses of schizophrenia and related psychoses were obtained from centralised hospital inpatient and outpatient registers up to age 27 years. Logistic regression calculated odds ratios (ORs) for psychotic outcomes associated

SUBMITTER: Metcalf SA 

PROVIDER: S-EPMC5176002 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature