The Moses-Littenberg meta-analytical method generates systematic differences in test accuracy compared to hierarchical meta-analytical models.

ABSTRACT:

Objective

To compare meta-analyses of diagnostic test accuracy using the Moses-Littenberg summary receiver operating characteristic (SROC) approach with those of the hierarchical SROC (HSROC) model.

Study design and setting

Twenty-six data sets from existing test accuracy systematic reviews were reanalyzed with the Moses-Littenberg model, using equal weighting ("E-ML") and weighting by the inverse variance of the log DOR ("W-ML"), and with the HSROC model. The diagnostic odds ratios (DORs) were estimated and covariates added to both models to estimate relative DORs (RDORs) between subgroups. Models were compared by calculating the ratio of DORs, the ratio of RDORs, and P-values for detecting asymmetry and effects of covariates on DOR.

Results

Compared to the HSROC mod

SUBMITTER: Dinnes J 

PROVIDER: S-EPMC5176007 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature