The LonDownS adult cognitive assessment to study cognitive abilities and decline in Down syndrome.

ABSTRACT:

Background

Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing Alzheimer's disease. However, there is individual variability in the onset of clinical dementia and in baseline cognitive abilities prior to decline, particularly in memory, executive functioning, and motor coordination. The LonDownS Consortium aims to determine risk and protective factors for the development of dementia and factors relating to cognitive abilities in people with DS. Here we describe our cognitive test battery and related informant measures along with reporting data from our baseline cognitive and informant assessments.

Methods

We developed a cognitive test battery to assess general abilities, memory, executive function,

SUBMITTER: Startin CM 

PROVIDER: S-EPMC5176078 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature