Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion.

ABSTRACT:

Background

Insulin secretion correlates inversely with insulin sensitivity, which may suggest the existence of a crosstalk between peripheral organs and pancreas. Such interaction might be mediated through glucose oxidation that may drive the release of circulating factors with action on insulin secretion.

Aim

To evaluate the association between whole-body carbohydrate oxidation and circulating factors with insulin secretion to consecutive oral glucose loading in non-diabetic individuals.

Methods

Carbohydrate oxidation was measured after an overnight fast and for 6 hours after two 3-h apart 75-g oral glucose tolerance tests (OGTT) in 53 participants (24/29 males/females; 34±9 y; 27±4 kg/m2). Insulin secretion was estimated by deconvolution of serum C-peptide concentra

SUBMITTER: Galgani JE 

PROVIDER: S-EPMC5176173 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature