Assessing Microstructural Substrates of White Matter Abnormalities: A Comparative Study Using DTI and NODDI.

ABSTRACT: Neurite orientation dispersion and density imaging (NODDI) enables more specific characterization of tissue microstructure by estimating neurite density (NDI) and orientation dispersion (ODI), two key contributors to fractional anisotropy (FA). The present work compared NODDI- with diffusion tensor imaging (DTI)-derived indices for investigating white matter abnormalities in a clinical sample. We assessed the added value of NODDI parameters over FA, by contrasting group differences identified by both models. Diffusion-weighted images with multiple shells were acquired in a group of 8 healthy controls and 8 patients with an inherited metabolic disease. Both standard DTI and NODDI analyses were performed. Tract based spatial statistics (TBSS) was used for group inferences, after which overla

SUBMITTER: Timmers I 

PROVIDER: S-EPMC5176300 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature