High-Sensitivity Cardiac Troponin, Statin Therapy, and Risk of Coronary Heart Disease.

ABSTRACT:

Background

Cardiac troponin is an independent predictor of cardiovascular mortality in individuals without symptoms or signs of cardiovascular disease. The mechanisms for this association are uncertain, and a role for troponin testing in the prevention of coronary heart disease has yet to be established.

Objectives

This study sought to determine whether troponin concentration could predict coronary events, be modified by statins, and reflect response to therapy in a primary prevention population.

Methods

WOSCOPS (West of Scotland Coronary Prevention Study) randomized men with raised low-density lipoprotein cholesterol and no history of myocardial infarction to pravastatin 40 mg once daily or placebo for 5 years. Plasma cardiac troponin I concentration was measured wit

SUBMITTER: Ford I 

PROVIDER: S-EPMC5176330 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature