SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.

ABSTRACT:

Background and purpose

SORL1 rs1699102 is associated with the risk of late-onset Alzheimer's disease. However, the effects of this single nucleotide polymorphism on cognition and brain structure during normal aging are unclear. This study aimed to examine the effects of the rs1699102 polymorphism on age-related cognitive decline and cortical gray matter reduction in the Chinese Han population.

Methods

A total of 780 non-demented adults completed a battery of neuropsychological tests. High-resolution T1-weighted structural magnetic resonance imaging data from 89 of these subjects were also collected using a Siemens Trio 3.0 Tesla scanner.

Results

The T allele carriers displayed an accelerated age-related change in episodic memory and processing speed tests relative to

SUBMITTER: Li H 

PROVIDER: S-EPMC5177470 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature