Effect of pretreatment with antifungal agents on clinical outcomes in fungal keratitis.

ABSTRACT:

Background

To determine if pretreatment with antifungal agents is predictive of worse clinical outcome in a fungal keratitis clinical trial.

Design

Non-pre-specified subgroup analysis of a randomized controlled trial in a tertiary hospital.

Participants

Three hundred twenty-three fungal ulcer cases with an enrolment visual acuity of 20/40 to 20/400.

Methods

The Mycotic Ulcer Treatment Trial I was a randomized, double-masked trial to determine the optimal treatment for filamentous fungal keratitis at the Aravind Eye Care System, India. Enrolled cases were randomized to receive topical natamycin or voriconazole. Prior antifungal medication use, dose and duration were collected at enrolment. A subgroup analysis was performed to determine if patients using natamyci

SUBMITTER: Sun CQ 

PROVIDER: S-EPMC5177485 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature