Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data.

ABSTRACT:

Background

Continued reductions in morbidity and mortality attributable to ischemic heart disease (IHD) require an understanding of the changing epidemiology of this disease. We hypothesized that we could use genetic correlations, which quantify the shared genetic architectures of phenotype pairs and extant risk factors from a historical prospective study to define the risk profile of a contemporary IHD phenotype.

Methods and results

We used 37 phenotypes measured in the ARIC study (Atherosclerosis Risk in Communities; n=7716, European ancestry subjects) and clinical diagnoses from an electronic health record (EHR) data set (n=19 093). All subjects had genome-wide single-nucleotide polymorphism genotyping. We measured pairwise genetic correlations (rG) between the ARIC and E

SUBMITTER: Mosley JD 

PROVIDER: S-EPMC5177499 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature