The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis.

ABSTRACT: Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that underlie these transitions are poorly understood. Here, we found that the chemokine receptor CX3CR1 identifies three distinct CD8⁺ Teff and Tmem subsets. Classical central (Tcm) and effector memory (Tem) cells and their corresponding Teff precursors were CX3CR1^- and CX3CR1^high, respectively. Viral infection also induced a numerically stable CX3CR1^int subset that represented ∼15% of blood-borne Tmem cells. CX3CR1^int Tmem cells underwent more frequent homeostatic divisions than other Tmem subsets and not only self-renewed, but also contributed to the expan

SUBMITTER: Gerlach C 

PROVIDER: S-EPMC5177508 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature