Association of estradiol with sleep apnea in depressed perimenopausal and postmenopausal women: a preliminary study.

ABSTRACT:

Objective

Women's risk of obstructive sleep apnea (OSA) increases substantially during and after the menopausal transition, when depression risk is also elevated, raising the possibility that estrogen withdrawal contributes to OSA vulnerability, in turn contributing to mood disturbance. We examined the association between estradiol levels and OSA in depressed peri- and postmenopausal women.

Methods

Thirty depressed peri-/postmenopausal women (mean body mass index [BMI] 30.82 kg/m) without known OSA completed routine polysomnography concurrent with serum estradiol levels. Estradiol in women with apnea-hypopnea indices (AHI) ≥15 indicating moderate-to-severe OSA was compared against those with AHI less than 15 using logistic regression adjusting for age and BMI.

Results

SUBMITTER: Galvan T 

PROVIDER: S-EPMC5177515 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature