A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control.

ABSTRACT: The drug development pipeline is severely limited by a lack of reliable tools for prediction of human clinical safety and efficacy profiles for compounds at the pre-clinical stage. Here we present the design and implementation of a platform technology comprising multiple human cell-based tissue models in a portable and reconfigurable format that supports individual organ function and crosstalk for periods of up to several weeks. Organ perfusion and crosstalk are enabled by a precision flow control technology based on electromagnetic actuators embedded in an arrayed format on a microfluidic platform. We demonstrate two parallel circuits of connected airway and liver modules on a platform containing 62 electromagnetic microactuators, with precise and controlled flow rates as well as function

SUBMITTER: Coppeta JR 

PROVIDER: S-EPMC5177565 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature