Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset.

ABSTRACT: Common marmosets (Callithrix jacchus) have recently gained popularity in biomedical research as models of aging research. Basically, they confer advantages from other non-human primates due to their shorter lifespan with onset of appearance of aging at 8 years. Old marmosets present some markers linked to neurodegeneration in the brain such as amyloid beta (Aβ)_1-42 and Aβ_1-40. However, there are no studies exploring other cellular markers associated with neurodegenerative diseases in this non-human primate. Using immunohistochemistry, we analyzed brains of male adolescent, adult, old, and aged marmosets. We observed accumulation of Aβ_1-40 and Aβ_1-42 in the cortex of aged subjects. Tau hyperphosphorylation was already detected in the brain

SUBMITTER: Rodriguez-Callejas JD 

PROVIDER: S-EPMC5177639 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature