Clinical spectrum of Castleman disease-associated neuropathy.

ABSTRACT:

Objective

To define the peripheral neuropathy phenotypes associated with Castleman disease.

Methods

We conducted a retrospective chart review for patients with biopsy-proven Castleman disease evaluated between January 2003 and December 2014. Patients with associated peripheral neuropathy were identified and divided into 2 groups: those with Castleman disease without POEMS syndrome (CD-PN) and those with Castleman disease with POEMS syndrome (CD-POEMS). We used a cohort of patients with POEMS as controls. Clinical, electrodiagnostic, and laboratory characteristics were collected and compared among patient subgroups.

Results

There were 7 patients with CD-PN, 20 with CD-POEMS, and 122 with POEMS. Patients with CD-PN had the mildest neuropathy characterized by predominant

SUBMITTER: Naddaf E 

PROVIDER: S-EPMC5177676 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature