Optic pathway glioma volume predicts retinal axon degeneration in neurofibromatosis type 1.

ABSTRACT:

Objective

To determine whether tumor size is associated with retinal nerve fiber layer (RNFL) thickness, a measure of axonal degeneration and an established biomarker of visual impairment in children with optic pathway gliomas (OPGs) secondary to neurofibromatosis type 1 (NF1).

Methods

Children with NF1-OPGs involving the optic nerve (extension into the chiasm and tracts permitted) who underwent both volumetric MRI analysis and optical coherence tomography (OCT) within 2 weeks of each other were included. Volumetric measurement of the entire anterior visual pathway (AVP; optic nerve, chiasm, and tract) was performed using high-resolution T1-weighted MRI. OCT measured the average RNFL thickness around the optic nerve. Linear regression models evaluated the relationship betwee

SUBMITTER: Avery RA 

PROVIDER: S-EPMC5177678 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature