A human brain network derived from coma-causing brainstem lesions.

ABSTRACT:

Objective

To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network.

Methods

We compared 12 coma-causing brainstem lesions to 24 control brainstem lesions using voxel-based lesion-symptom mapping in a case-control design to identify a site significantly associated with coma. We next used resting-state functional connectivity from a healthy cohort to identify a network of regions functionally connected to this brainstem site. We further investigated the cortical regions of this network by comparing their spatial topography to that of known networks and by evaluating their functional connectivity in patients with disorders of consciousness.

Results

A small region in the rostral dorsolateral pontine tegmentum was signi

SUBMITTER: Fischer DB 

PROVIDER: S-EPMC5177681 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature