Pathway-Specific Dopamine Abnormalities in Schizophrenia.

ABSTRACT: In light of the clinical evidence implicating dopamine in schizophrenia and the prominent hypotheses put forth regarding alterations in dopaminergic transmission in this disease, molecular imaging has been used to examine multiple aspects of the dopaminergic system. We review the imaging methods used and compare the findings across the different molecular targets. Findings have converged to suggest early dysregulation in the striatum, especially in the rostral caudate, manifesting as excess synthesis and release. Recent data showed deficit extending to most cortical regions and even to other extrastriatal subcortical regions not previously considered to be "hypodopaminergic" in schizophrenia. These findings yield a new topography for the dopaminergic dysregulation in schizophrenia. We disc

SUBMITTER: Weinstein JJ 

PROVIDER: S-EPMC5177794 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature