Analysis of CXCR5⁺Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis.

ABSTRACT: Th17 and TfH cells are thought to promote tissue inflammation and autoantibody production, respectively, in autoimmune diseases including rheumatoid arthritis (RA). TfH cells that co-express Th17 markers (CXCR5⁺Th17) encompass both of these pathogenic functions, and are increased in some human autoimmune settings including juvenile dermatomyositis. We investigated CXCR5⁺Th17 cells in RA subjects with stable or active disease and before and after TNF inhibitor therapy. CXCR5⁺Th17 cell frequency was increased in RA compared to healthy controls, but other helper T cell subsets were not different. CXCR5⁺Th17 cells correlated with disease activity in subjects with active RA prior to initiation of TNF inhibitor therapy. Baseline CXCR5⁺Th17 c

SUBMITTER: Singh D 

PROVIDER: S-EPMC5177940 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature