Interactions of established risk factors and a GWAS-based genetic risk score on the risk of venous thromboembolism.

ABSTRACT: Multiple genetic and environmental risk factors contribute to venous thromboembolism (VTE) risk. Understanding how genes and environmental risk factors interact may provide key insight into the pathophysiology of VTE and may identify opportunities for targeted prevention and treatment. It was our aim to examine the main effects and the potential effect-modification between single nucleotide polymorphisms (SNPs) at established loci and lifestyle risk factors for VTE. We performed a nested case-control study using data on 1,040 incident VTE cases and 16,936 controls from the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study cohorts, who gave blood, were selected as participants in a previous genome-wide association study (GWAS), and completed a biennial

SUBMITTER: Crous-Bou M 

PROVIDER: S-EPMC5177985 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature