The features of mucosa-associated microbiota in primary sclerosing cholangitis.

ABSTRACT:

Background

Little is known about the role of the microbiome in primary sclerosing cholangitis.

Aim

To explore the mucosa-associated microbiota in primary sclerosing cholangitis (PSC) patients across different locations in the gut, and to compare it with inflammatory bowel disease (IBD)-only patients and healthy controls.

Methods

Biopsies from the terminal ileum, right colon, and left colon were collected from patients and healthy controls undergoing colonoscopy. Microbiota profiling using bacterial 16S rRNA sequencing was performed on all biopsies.

Results

Forty-four patients were recruited: 20 with PSC (19 with PSC-IBD and one with PSC-only), 15 with IBD-only and nine healthy controls. The overall microbiome profile was similar throughout different locations i

SUBMITTER: Torres J 

PROVIDER: S-EPMC5177987 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature