Pneumovirus-Induced Lung Disease in Mice Is Independent of Neutrophil-Driven Inflammation.

ABSTRACT: The human pneumovirus respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract disease in young children worldwide. A hallmark of severe human RSV infection is the strong neutrophil recruitment to the airways and lungs. Massive neutrophil activation has been proven detrimental in numerous diseases, yet in RSV the contribution of neutrophils to disease severity, and thereby, the relevance of targeting them, is largely unknown. To determine the relevance of potential neutrophil targeting therapies, we implemented antibody-mediated neutrophil depletion in a mouse pneumonia virus of mice (PVM) model. PVM is a host specific murine pneumovirus closely related to human RSV, which reproduces many of the features of RSV infection, such as high viral replication

SUBMITTER: Cortjens B 

PROVIDER: S-EPMC5179008 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature