Metal-free ¹⁸F-labeling of aryl-CF₂H via nucleophilic radiofluorination and oxidative C-H activation.

ABSTRACT: A metal-free and selective method to form [¹⁸F]aryl-CF₂H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.

SUBMITTER: Yuan G 

PROVIDER: S-EPMC5179041 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature