Neural Crest Migration and Survival Are Susceptible to Morpholino-Induced Artifacts.

ABSTRACT: The neural crest (NC) is a stem cell-like embryonic population that is essential for generating and patterning the vertebrate body, including the craniofacial skeleton and peripheral nervous system. Defects in NC development underlie many birth defects and contribute to formation of some of the most malignant cancers in humans, such as melanoma and neuroblastoma. For these reasons, significant research efforts have been expended to identify genes that control NC development, as it is expected to lead to a deeper understanding of the genetic mechanisms controlling vertebrate development and identify new treatments for NC-derived diseases and cancers. However, a number of inconsistencies regarding gene function during NC development have emerged from comparative analyses of gene function bet

SUBMITTER: Boer EF 

PROVIDER: S-EPMC5179070 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature