NETosis before and after Hyperglycemic Control in Type 2 Diabetes Mellitus Patients.

ABSTRACT:

Introduction and objective

Diabetes is characterized by chronic inflammation, endothelial dysfunction, increased risk of infections and early cardiovascular disease. By releasing neutrophil extracellular traps (NETs), neutrophils kill bacteria and exert pro-inflammatory and pro-thrombotic activities. Increased NETosis has been found in cross-sectional studies including treated type 2 diabetes mellitus (T2DM) patients. In this study, we determined whether the ability of neutrophils to form NETs differs in diabetic patients pre- and post-hyperglycemic control versus healthy donors (HD), and the relationship between NETosis with pro-thrombotic, pro-inflammatory biomarkers and thrombotic clinical events.

Methods

Diabetic patients recently diagnosed and after 6 and 12 months of t

SUBMITTER: Carestia A 

PROVIDER: S-EPMC5179097 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature