Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia.

ABSTRACT:

Background

Malaria burden in Brazil has reached its lowest levels in 35 years and Plasmodium vivax now accounts for 84% of cases countrywide. Targeting residual malaria transmission entrenched in the Amazon is the next major challenge for ongoing elimination efforts. Better strategies are urgently needed to address the vast reservoir of asymptomatic P. vivax carriers in this and other areas approaching malaria elimination.

Methods

We evaluated a reactive case detection (RCD) strategy tailored for P. vivax transmission in farming settlements in the Amazon Basin of Brazil. Over six months, 41 cases detected by passive surveillance triggered four rounds of RCD (0, 30, 60, and 180 days after index case enrollment), using microscopy- and quantitative real-time polymerase chain re

SUBMITTER: Fontoura PS 

PROVIDER: S-EPMC5179126 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature