Performance evaluation of commercial short-oligonucleotide microarrays and the impact of noise in making cross-platform correlations.

ABSTRACT:

Background

Despite the widespread use of microarrays, much ambiguity regarding data analysis, interpretation and correlation of the different technologies exists. There is a considerable amount of interest in correlating results obtained between different microarray platforms. To date, only a few cross-platform evaluations have been published and unfortunately, no guidelines have been established on the best methods of making such correlations. To address this issue we conducted a thorough evaluation of two commercial microarray platforms to determine an appropriate methodology for making cross-platform correlations.

Results

In this study, expression measurements for 10,763 genes uniquely represented on Affymetrix U133A/B GeneChips and Amersham CodeLink UniSet Human 20 K mic

SUBMITTER: Shippy R 

PROVIDER: S-EPMC517929 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature