Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivity.

ABSTRACT: Examination of intrinsic functional connectivity using functional MRI (fMRI) has provided important findings regarding dysconnectivity in schizophrenia. Extending these results using a complementary neuroimaging modality, magnetoencephalography (MEG), we present the first direct comparison of functional connectivity between schizophrenia patients and controls, using these two modalities combined. We developed a novel MEG approach for estimation of networks using MEG that incorporates spatial independent component analysis (ICA) and pairwise correlations between independent component timecourses, to estimate intra- and intern-network connectivity. This analysis enables group-level inference and testing of between-group differences. Resting state MEG and fMRI data were acquired from a large

SUBMITTER: Houck JM 

PROVIDER: S-EPMC5179295 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature