Regional brain volume changes in alcohol-dependent individuals during early abstinence: associations with relapse following treatment.

ABSTRACT: Cross-sectional structural magnetic resonance (MR) imaging studies of individuals with an alcohol use disorder (AUD) report that those who relapse after treatment, relative to individuals who maintain a period of extended abstinence, show greater morphological abnormalities in multiple brain regions near the inception of treatment, particularly in the frontal lobe. However, given the cross-sectional design of previous studies, it is unclear if the baseline morphological differences between future abstainers and relapsers were maintained over the course of early recovery. The primary goal of this study was to determine if frontal lobe tissue volume recovery during early abstinence is associated with long-term abstinence from alcohol. We compared frontal, parietal, temporal and occipital gre

SUBMITTER: Durazzo TC 

PROVIDER: S-EPMC5179312 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature