Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.

ABSTRACT: Breast cancer is one of the most common malignancies among women worldwide. Genetic factors have been shown to play an important role in breast cancer aetiology. We conducted a two-stage genome-wide association study (GWAS) including 14 224 cases and 14 829 controls of East Asian women to search for novel genetic susceptibility loci for breast cancer. Single nucleotide polymorphisms (SNPs) in two loci were found to be associated with breast cancer risk at the genome-wide significance level. The first locus, represented by rs12118297 at 1p22.3 (near the LMO4 gene), was associated with breast cancer risk with odds ratio (OR) and (95% confidence interval (CI)) of 0.91 (0.88-0.94) and a P-value of 4.48 × 10^{-  8} This association was replicated in another study, DRIVE GAME-

SUBMITTER: Han MR 

PROVIDER: S-EPMC5179918 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature