Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer.

ABSTRACT: Predicting response to endocrine therapy and survival in oestrogen receptor positive breast cancer is a significant clinical challenge and novel prognostic biomarkers are needed. Long-range regulators of gene expression are emerging as promising biomarkers and therapeutic targets for human diseases, so we have explored the potential of distal enhancer elements of non-coding RNAs in the prognostication of breast cancer survival. HOTAIR is a long non-coding RNA that is overexpressed, promotes metastasis and is predictive of decreased survival. Here, we describe a long-range transcriptional enhancer of the HOTAIR gene that binds several hormone receptors and associated transcription factors, interacts with the HOTAIR promoter and augments transcription. This enhancer is dependent on Forkhead-

SUBMITTER: Milevskiy MJ 

PROVIDER: S-EPMC5179926 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature