Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.

ABSTRACT: Mouse models of the transcriptional modulator Methyl-CpG-Binding Protein 2 (MeCP2) have advanced our understanding of Rett syndrome (RTT). RTT is a 'prototypical' neurodevelopmental disorder with many clinical features overlapping with other intellectual and developmental disabilities (IDD). Therapeutic interventions for RTT may therefore have broader applications. However, the reliance on the laboratory mouse to identify viable therapies for the human condition may present challenges in translating findings from the bench to the clinic. In addition, the need to identify outcome measures in well-chosen animal models is critical for preclinical trials. Here, we report that a novel Mecp2 rat model displays high face validity for modelling psychomotor regression of a learned skill, a deficit

SUBMITTER: Veeraragavan S 

PROVIDER: S-EPMC5179927 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature