A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives.

ABSTRACT: Comparative assessment of potential human health impacts is a critical step in evaluating both chemical alternatives and existing products on the market. Most alternatives assessments are conducted on a chemical-by-chemical basis and it is seldom acknowledged that humans are exposed to complex products, not individual substances. Indeed, substances of Unknown or Variable composition, Complex reaction products, and Biological materials (UVCBs) are ubiquitous in commerce yet they present a major challenge for registration and health assessments. Here, we present a comprehensive experimental and computational approach to categorize UVCBs according to global similarities in their bioactivity using a suite of in vitro models. We used petroleum substances, an i

SUBMITTER: Grimm FA 

PROVIDER: S-EPMC5179981 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature