Experimental immunological demyelination enhances regeneration in autograft-repaired long peripheral nerve gaps.

ABSTRACT: Peripheral nerve long gap defects are a clinical challenge in the regeneration field. Despite the wide variety of surgical techniques and therapies, autografting is the "gold standard" for peripheral nerve gap reconstruction. The pathological process of Wallerian degeneration from the time of acute injury to efficient regeneration requires several weeks. Regeneration time is critical for nerve reconstruction. Immunological demyelination induced by anti-galactocerebroside antibodies plus guinea pig complement was used to shorten the treatment time. Based on an antigen-antibody complex reaction, the demyelinating agent induced an acute and severe demyelination, leading to the pathological process of Wallerian degeneration during the demyelinating period. This method was used to treat a 12 mm

SUBMITTER: Ge J 

PROVIDER: S-EPMC5180223 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature