Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer's disease.

ABSTRACT: Many studies have shown that imbalance of mineral metabolism may play an important role in Alzheimer's disease (AD) progression. It was recently reported that selenium could reverse memory deficits in AD mouse model. We carried out multi-time-point ionome analysis to investigate the interactions among 15 elements in the brain by using a triple-transgenic mouse model of AD with/without high-dose sodium selenate supplementation. Except selenium, the majority of significantly changed elements showed a reduced level after 6-month selenate supplementation, especially iron whose levels were completely reversed to normal state at almost all examined time points. We then built the elemental correlation network for each time point. Significant and specific elemental correlations and correlation cha

SUBMITTER: Zheng L 

PROVIDER: S-EPMC5180247 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature