Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life.

ABSTRACT:

Objectives

To investigate the association between reproductive history indicators of hormonal exposure, including reproductive period, pregnancy, and use of hormonal contraceptives, and mid- and late-life cognition in postmenopausal women.

Design

Analysis of baseline data from two randomized clinical trials: the Women's Isoflavone Soy Health and the Early vs Late Intervention Trial of Estradiol.

Setting

University academic research center.

Participants

Naturally menopausal women (N = 830).

Measurements

Participants were uniformly evaluated using a cognitive battery and a structured reproductive history questionnaire. Outcomes were composite scores for verbal episodic memory, executive function, and global cognition. Reproductive variables included ages a

SUBMITTER: Karim R 

PROVIDER: S-EPMC5180359 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature